(1877-1968), neuropsychiatrist Frederick Lucien Golla was born in Fulham, London on 11 August 1877 to Italian parents Peter Alexander Evasio Golla and Alice Amelia Tingey. He was educated at Tonbridge School and Magdalen College, Oxford, before pursuing medical training at St George’s Hospital, London. He graduated in 1904 and became resident medical officer at the National Hospital for Nervous Diseases, Queen Square, under surgeon Victor Horsley (1857-1916) and neurologist Gordon Holmes (1876-1965), where he began to pursue research into the human nervous system. During the First World War, Golla volunteered for field ambulance duty with the Royal Army Medical Corps in August 1914 and was invalided out of the army after contracting bronchial pneumonia in June 1915. In August 1915, he returned to the Royal Army Medical Corps and rose to the rank of captain. His wartime research on tetanus was widely celebrated, leading to his post-war promotion to consultant physician at St George’s Hospital, where he worked on nervous conduction with neurophysiologist Charles Scott Sherrington (1857-1952). In 1923, Golla was appointed director of the Central Pathological Laboratory at the Maudsley Hospital, London. As well as controlling the educational programme of the Maudsley Hospital medical school, Golla continued to conduct research with junior colleagues. In the 1930s, he collaborated with neurophysiologist William Grey Walter (1910-1977) in pioneering studies of electroencephalography (EEG, the measurement of the electrical activity of the brain), including the first detection of a cerebral tumour using the technique in 1936. In 1939, Golla was invited to become director of the new Burden Neurological Institute, Bristol, an independent research unit specialising in the investigation and treatment of neurological, psychological, and psychiatric disorders. Under Golla’s direction, the Burden achieved several ‘firsts’ in British psychiatry, including the first trials of electro-convulsive therapy (ECT) in 1939 and the first leucotomy (lobotomy) in 1941. He retired from the Burden in 1959. Golla was married twice, first to Thérèse d'Haussaire in 1908, who fatally contracted bronchial pneumonia while nursing Golla back to health in 1915, and then to Yvonne Lilly Brisco Ray in 1919. He had one daughter, Yolande Golla, who would later co-author research at the Burden Neurological Institute. Golla died of heart failure on 6 February 1968.

biochemist, active 1950s Leslie D. MacLeod was a biochemist and researcher at the Burden Neurological Institute, Bristol, an independent research unit specialising in the investigation and treatment of neurological, psychological, and psychiatric disorders. His research focused on the effects of alcohol and alcohol addiction on the brain and was supported by funds from the Society for the Study of Addiction.

(1910-1977), neurophysiologist William Grey Walter (also known as Grey Walter) was born in Kansas City, Missouri, on 19 February 1910 to journalist parents Karl Wilhelm Walter (1880-1965) and Minerva (Margaret) Lucrezia Hardy (1879-1953). The Walter family moved from the United States to Britain in 1915, where William remained for the rest of his life. He was educated at Westminster School (1922-1928), before taking the Natural Science Tripos at King’s College, Cambridge (1928-1931). He went on to pursue postgraduate research on nerve physiology and conditioned reflexes, gaining his MA in 1935. After completing his MA, Walter was invited to work at the Central Pathological Laboratory of the Maudsley Hospital, London, under neuropsychiatrist Frederick Lucien Golla (1877-1968). Since the late 1920s, Golla had become increasingly interested in the clinical applications of the burgeoning field of electroencephalography (EEG), the measurement of the electrical activity of the brain via electrodes placed on the scalp. Noting his skill in technical matters, Golla encouraged Walter to develop increasingly sophisticated EEG devices, and supported his application for a Rockefeller Travelling Fellowship to visit the Jena laboratory of German physiologist Hans Berger (1873-1941), widely credited as the founder of electroencephalography. Walter went on to achieve several key ‘firsts’ in electroencephalography, including the first detection of a cerebral tumour using the technique in 1936. Between 1936 and 1939, Walter expanded his research programme and took readings from hundreds of patients, focusing particularly on the electrical patterns of epilepsy. In 1939, Golla was invited to become director of the new Burden Neurological Institute, Bristol, an independent research unit specialising in the investigation and treatment of neurological, psychological, and psychiatric disorders, and invited Walter to become director of the Institute’s Physiology Department. At the Burden, Walter further developed his EEG apparatus, developing the automatic frequency analyser and the toposcope in 1943 and 1950 respectively. His research programme also became increasingly ambitious, with investigations into the cerebral effects of stroboscopic light beginning in 1947 and, later, the discovery of ‘contingent negative variation’ (CNV, or the ‘expectancy wave’) in the 1960s. Walter also played a key role in the professionalization of electroencephalography during this period, co-founding the journal Electroencephalography and Clinical Neurophysiology and organising meetings of the EEG Society (1943-1989). Outside of his clinical work, Walter became a key figure in early British cybernetics, the study of feedback, control, and communication systems in humans and machines that synthesised approaches from engineering, biology, and mathematics. He co-founded the Ratio Club, an informal dining and discussion group which provided a key social outlet for cybernetic enthusiasts, which met between 1949 and 1955. He also built several cybernetic devices in his spare time, the most famous of which were his robotic tortoises, or Machina Speculatrix, designed to function as simple models of the adaptable human brain. These received national attention when they were exhibited on television in 1950 and at the Festival of Britain in 1951. He also became a prolific public intellectual, writing 170 scientific publications, serving as an expert witness in court courses, appearing frequently on the BBC, and writing an immensely popular non-specialist text on his neuroscientific work, The Living Brain (1953). His work also gained a surprising popularity among counter-cultural artists during the 1950s and 1960s, including Beat writers William S. Burroughs and Allen Ginsberg, who saw Walter’s research as part of a broader investigation of human consciousness. Walter was married twice, first to Katharine Monica Ratcliffe in 1934 and then to Vivian Joan Dovey (1915-1980) in 1947, with whom he had one son, Timothy Walter (1949-1976). Walter and Dovey separated in 1960 and divorced in 1973. After their separation, Walter lived with Lorraine Josephine Aldridge (née Donn) until 1972. In 1970, Walter suffered severe brain damage following a road accident, forcing him to retire from full-time research work. He died of a heart attack in 1977.

(1900-1970), endocrinologist Max Reiss was born in Stanislau (now Ivano-Frankivsk), western Ukraine on 1 May 1900. He received his medical education from the German University of Prague and worked as a demonstrator and assistant in the clinic of endocrinologist Artur Biedl (1869-1930) before qualifying in 1925. After this, Reiss expanded his clinical and experimental interests in endocrinology, particularly focusing on the influence of gonadal and anterior pituitary hormones on metabolic processes. With the outbreak of the Second World War in 1939, Reiss was forced to flee from Prague and came to Britain on the invitation of neuropsychiatrist Frederick Lucien Golla (1878-1968). Golla provided Reiss with a research post at the Burden Neurological Institute, Bristol, an independent research unit specialising in the investigation and treatment of neurological, psychological, and psychiatric disorders. Reiss later became Director of the Institute’s Endocrinological Department. While at the Burden, Reiss was a key player in establishing the field of ‘psychoneuroendocrinology’ (the study of the interactions between genetics and hormones in cases of psychiatric illness and mental disability) and encouraged the expansion of endocrinological treatments in various Bristol psychiatric hospitals. In the early 1960s, Reiss promoted this approach in the United States through his new role as Director of Psychiatric Research at the Willowbrook State School in Staten Island, New York, where he made several investigations into potential links between mental disability and reduced growth hormone levels. Willowbrook later attained international notoriety for hepatitis experiments conducted on children in its care and was shut down in 1987. Max Reiss died suddenly of an embolism in Wolfeboro, New Hampshire on 27 July 1970.

biochemist, active 1950s Arthur Tingey was a biochemist and researcher at the Burden Neurological Institute, Bristol, an independent research specialising in the investigation and treatment of neurological, psychological, and psychiatric disorders. His research focused on the neurochemical aspects of various psychiatric and neurological conditions, including leukodystrophy and Niemann-Pick disease.