Ferranti Ltd began working on computers in 1947, and by 1949 had established a Computer Group within the company. The Group worked with academic researchers, notably at the Universities of Manchester and Cambridge, and delivered the world's first commercially available computer in 1951: the Ferranti Mark 1. The collaboration with Manchester went on to produce the Ferranti Mercury and Atlas, whilst work with Cambridge led to the Atlas 2 or Titan. In 1953-1955 Ferranti set up a sales and development centre in central London, at Portland Place, in order to encourage a market for their products. A Pegasus computer was built on site. Other machines developed in the 1950s included the Pegasus II and Perseus models, as well as the Orion models. These machines were found to be useful in the aerospace industry and for nuclear research. From 1958-1962 Ferranti attempted to dramatically improve performance with a completely new design of computer: the Atlas. Background research was carried out at the University of Manchester and was known as the MUSE project. In 1963 the computer department was sold to International Computers and Tabulators. However, Ferranti continued to produce computers for the industrial sector through the Ferranti-Packard division, and work continued at the company's Bracknell, Wythenshawe and Cheadle Heath sites in industrial computing, automation and military computing. In the 1960s and 1970s the company developed its Argus models. Ferranti Computer Systems Ltd was formed in 1977 to bring together Ferranti’s computing divisions at Bracknell (digital systems), Wythenshawe (automation), and Cheadle Heath (military systems). The new company had a workforce of 4,400 and a £30 million pound annual turnover. The company was successful throughout the late 1970s and into the 1980s. Ferranti Computer Systems developed and manufactured control, monitoring and communication systems for industrial processes such as oil and gas extraction, public utilities, data communications networks and road transport. They were also involved in information systems including for air transport, providing data processing terminals, office systems, industrial and commercial local area networks. The company also supplied equipment to end users. As well as being active in the UK, by 1988 the company had subsidiaries in Australia, West Germany, Belgium and America. In 1994 Ferranti entered receivership. The computing division was sold to a division of Thomson-CSF, known as SYSECA. The company adopted the name Ferranti-SYSECA, which fell out of use around 1996. Ferranti Computer Systems merged with Thales UK in 2000, whereupon all operations were moved to Cheadle Heath on the outskirts of Manchester.

Dr Philip Holland Price was a lecturer in the Nuclear Engineering Department of the Victoria University of Manchester (later University of Manchester). He used computational fluid dynamics in the design of Manchester's first nuclear reactor. The calculations necessary to the process were carried out on a Ferranti Pegasus computer.