(1891-1940), philanthropist Rosa Gladys Burden (née Williams) served as superintendent of the Stoke Park Colony, Bristol, around the time of the First World War. The Colony had been founded by the missionary and philanthropist couple Reverend Harold Nelson Burden (1860-1930) and Katherine Mary Burden (1856-1919) as an institution for the separation, rehabilitation, and occupational training of individuals with mental disabilities. Rosa became a close friend of the Burdens in her superintendent role, and, following Katherine’s death from a stroke in 1919, Harold and Rosa married on 12 May 1920. For the next decade, Rosa continued to support the Colony’s work and that of its charitable trust, the National Institutions for Persons Requiring Care and Control (NIPRCC). Following Harold Burden’s death from heart disease in 1930, Rosa took over his position as Warden of the NIPRCC and expanded his sponsorship of medical research at the Stoke Park Colony. She established the Burden Research Trust in 1933, a £10,000 fund to support medical and psychiatric studies of the Colony’s inhabitants. In 1936, the Trust oversaw the building of a dedicated clinic for the study of epilepsy, with a fully-fitted operating theatre, two small wards, and several laboratories. The clinic was officially opened on 12 May 1939 as the Burden Neurological Institute, under the directorship of neuropsychiatrist Frederick Lucien Golla (1878-1968). The Institute would go on to establish itself as a pioneering neuroscientific research unit in the latter half of the twentieth-century. Rosa Burden died shortly after the opening of the Institute, on 17 September 1940.

The National Institutions for Persons Requiring Care and Control (NIPRCC) was a charitable trust founded by missionary and philanthropist Harold Nelson Burden (1859-1930) in 1902. The NIPRCC was responsible for the funding, maintenance, and direction of a network of institutions for the care and treatment of individuals with mental disabilities, located in Bristol and its surrounding areas. Motivated by the poor conditions he observed while serving as chaplain of Bristol’s Horfield Prison in the 1890s, particularly those of prisoners suffering from alcoholism and mental disability, Burden established the NIPRCC in 1902 to advocate for institutional solutions to the housing and care of vulnerable individuals. In the following years, the NIPRCC became a key player in changing government policies on institutional care, in great part due to Burden’s involvement in the 1904 Royal Commission for the Care and Control of the Feeble-Minded. The subsequent Mental Deficiency Act of 1913, which mandated the removal of those with mental disabilities from the country’s prisons and workhouses, ultimately supported the NIPRCC’s aim of institutionally separating such individuals into newly built ‘colonies’. The first institution to be certified under the 1913 law was the Stoke Park Colony in Bristol, established by Burden and the NIPRCC in 1909. Built on the site of Dower House, an eighteenth-century manor bought from the Duke of Beaufort in 1901, the Stoke Park Colony was held up as an exemplary site where individuals with mental disabilities could be given both medical care and occupational training, such as lessons in weaving, gardening, and carpentry. In 1917, the Colony was granted an extended licence to house 1,528 ‘inmates’, making it the largest licenced institution in the country. In the years following the establishment of the National Health Service (NHS) in 1948, many NIPRCC institutions, including the Stoke Park Colony, were handed over to the Ministry of Health. The NIPRCC remained active in its original form until the mid-1950s, before changing its name to the Burden Trust. The Trust remains active today as a non-fundraising charity which provides grants for hospitals, medical research centres, retirement homes, and schools.

The Burden Neurological Institute (BNI) is an independently-funded research unit and registered charity specialising in the investigation and treatment of neurological, psychological, and psychiatric disorders. The BNI opened in 1939 at the Stoke Park Colony in Bristol, England. The BNI was named after philanthropist Rosa Gladys Burden (1891-1939). Burden’s husband, Reverend Harold Nelson Burden (1859-1930), founded the Stoke Park Colony with his first wife Katherine Mary Burden (1856-1919) in 1909. The Colony became the first certified institution for the care of individuals with mental disorders in Britain following the passing of the 1913 Mental Deficiency Act. After Harold Burden’s death in 1930, Rosa continued his sponsorship of medical research by founding the Burden Research Trust in 1933, a £10,000 research fund to support medical and psychiatric studies of the Colony’s patients. In 1936, the Trust built a dedicated epilepsy clinic on site with a fully-fitted operating theatre, two small wards, and several laboratories. The clinic was officially opened on 12 May 1939 as the Burden Neurological Institute, under the directorship of neuropsychiatrist Frederick Lucien Golla (1878-1968). The BNI’s work was soon disrupted by the outbreak of the Second World War in September 1939. Throughout the conflict, the site was used as a neurosurgical hospital by the Emergency Medical Service (1938-1945), a state-run network of free hospital services organised by the Ministry of Health. Despite these duties, the laboratories remained open and research projects continued, such as a programme of electroencephalographic (EEG) research on war casualties who had sustained head injuries. Following the end of the war and the establishment of the National Health Service (NHS) in 1948, Golla fought to keep the BNI independent to ensure that researchers could continue to choose their own projects. The BNI did, however, provide neurophysiological services for nearby hospitals for an annual fee. From its foundation, the BNI took a leading role in the development of neurological and psychiatric expertise in Britain. Researchers at the BNI carried out the country’s first trial of electro-convulsive therapy (ECT) in 1939, closely followed by the first prefrontal leucotomy in 1940. The BNI also established itself as a centre of innovation in engineering, cybernetics, and early robotics during the post-war years, due in great part to the work of neurophysiologist William Grey Walter (1910-1977). Walter’s best-known inventions, his Machina Speculatrix (small robotic tortoises designed to model the basic functions of the human brain) attracted national attention, appearing in newspapers, on television, and at the Festival of Britain in 1951. After several years of financial uncertainty, the Trustees of the Burden estate sold the Stoke Park site to the Ministry of Health in 1968. While clinical work continued under the NHS at the newly constituted Burden Neurological Hospital, the Institute’s scientific researchers decided to remain separate, turning the BNI into a Company Limited by Guarantee in 1970. In 2000, the BNI moved its headquarters to the Rosa Burden Centre at Southmead Hospital, Bristol, following the final closure of the Stoke Park site in the late 1990s.